Mpox Preparedness and Response Plan for Africa 2025

Regional Plan
CRP last updated: December 17 2024
$46,091,778
Funding required
3,812,196
People Targeted
63
Entities targeted

IOM aims to prepare for and respond to the potential further spread of mpox cases and mitigate the spread across the African continent. IOM will support governments and communities to address the mobility dimensions of public health threats and ensure that affected and at-risk populations benefit from appropriate and timely support.  IOM will support in preventing, detecting, and responding to mpox and other communicable disease outbreaks focusing on points of entry (PoE) and exit, key congregation points along mobility corridors, and sites for displaced people, other mobile populations and cross-border communities. 

A Nurse observes patient conditions at the Nyiragongo mpox treatment centreer, Democratic Republic of the Congo border © IOM 2024/Antoine Lemonnier

The multi-country mpox outbreak, first reported in 2022, has spread rapidly since the beginning of 2024 due to a new mpox variant. This led to the declaration of a Public Health Emergency of Continental Security by Africa Centres of Disease Control and Prevention (Africa CDC) and a Public Health Emergency of International Concern under the International Health Regulations (2005) (IHR) by the World Health Organization (WHO) in August 2024. 

As of 31 October 2024, the WHO has reported over 10,722 confirmed cases including 36 deaths in 19 countries across Africa (Burundi, Cameroon, Central African Republic, Congo, Côte d’Ivoire, Democratic Republic of the Congo [DRC], Gabon, Ghana, Guinea, Kenya, Liberia, Mauritius, Morocco, Nigeria, Rwanda, South Africa, Uganda, Zambia, and Zimbabwe)  (WHO, 2024).  More than 80 per cent of confirmed cases were reported in DRC, followed by Burundi at 14 per cent.  Nine of the affected countries reported their first mpox case this year. 

In addition to the mpox outbreak, the Ministry of Health (MoH) of Rwanda confirmed the country’s first outbreak of Marburg virus disease (MVD) on 27 September 2024 and the MoH of South Sudan declared a cholera outbreak on 28 October 2024, further compounding ongoing cholera and acute watery diarrhea outbreaks in 19 countries across Africa.  

The complexity and severity of disease outbreaks occurring across the continent is placing a heavy burden on under-resourced health systems. Marginalized and hard-to-reach populations, including refugees, internally displaced persons (IDPs), migrants, and other highly mobile populations (including truck, bus, taxi, and motorcycle drivers; fishing communities; and sex workers), often face significant barriers in accessing essential healthcare services, which further increases their vulnerability to health risks.

At the headquarters level, IOM actively participates in the Global Outbreak Alert and Response Network (GOARN) led by WHO. As a member of the Global Health Cluster and an active participant in the Inter-Agency Standing Committee (IASC), IOM coordinates closely with United Nations (UN) agencies, the U.S. Centers for Disease Control and Prevention (CDC), donors, other clusters, and committee actors to ensure a holistic response in its health programming.  

At the continental level, IOM participates in continental coordination meetings on mpox and MVD preparedness and response activities with Member States, UN agencies, partners and donors. As a leading organization for the PoE under surveillance pillar in the Mpox Continental Preparedness and Response Plan for Africa, IOM chairs the PoE Technical Working Group (TWG) meetings in partnership with the Africa CDC and WHO to support Member States on PoE response. 

At the regional level, the IOM Regional Office for East, Horn, and Southern Africa (EHSA) participates in the Health Group Partner meeting, a joint Eastern African regional meeting led by Africa CDC, and the IOM Regional Office for West and Central Africa (WCA) also participates in relevant regional coordination meetings. Through participation in these meetings, IOM coordinates with UN agencies, the Africa CDC, Regional Economic Communities (East African Community, Intergovernmental Authority on Development, and Economic Community of West African States), partners, and donors for the regional response to mpox and other health emergencies.

IOM, as a leading organization for the PoE sub-pillar in the Mpox Continental Preparedness and Response Plan for Africa and a leading global actor on migration health, responds to the health needs of migrants including IDPs, refugees, and highly mobile populations throughout all phases of the migration process, as well as to the public health needs of host communities by strengthening health systems and migration policies and practices. IOM has substantial experience in responding to public health emergencies including Ebola Virus Disease (EVD), COVID-19, mpox, cholera, measles, and other disease outbreaks at the national and regional levels, particularly with regard to understanding human mobility and border surveillance and management during extraordinary circumstances, including the influx of IDPs and refugees and health outbreaks . The Organization’s health and cross-sectoral expertise is in part based on IOM’s Health, Border and Mobility Management Framework (HBMM) developed during the West Africa EVD outbreak.  

Through the HBMM framework, IOM delivers and promotes comprehensive preventive and curative health programmes, which are beneficial, accessible, and equitable for migrants and other mobile populations, and local populations worldwide. IOM does this by assisting governmental and non-governmental partners in the development and implementation of relevant programmes and policies to prevent, detect and respond to potential health threats along the mobility continuum (at points of origin, transit, destination and return).

This mpox preparedness and response plan aims to support governments to address the mobility dimensions of public health threats by supporting governments to conduct needs assessments and PMM, capacity strengthening, technical support to develop standard operating procedures (SOPs) and policies, assisting coordination within countries and across borders. At the regional level, IOM supports Member States to facilitate multi-country dialogue and coordination. 

At the country level, IOM supports governments to meet IHR requirements for public health emergency preparedness and response at PoEs. IOM supports national mpox initiatives led by the MoH and engages with relevant government actors to support PoE health interventions. IOM works closely with local authorities to ensure that outreach activities are culturally appropriate, sensitive, and acceptable to community members to maximize their impact.

For example, IOM Tanzania  supports the government at the national and regional levels to address health emergency situations. IOM Tunisia supports the MoH to improve its IHR capacities at PoEs. IOM Uganda supported the government to integrate crisis response measures into the broader national development plan and mpox national response plan. IOM Zambia actively engaged with the MoH through participating in national and regional mpox coordination platforms. IOM Zimbabwe supports the government to strengthen global health security at PoEs. IOM in Benin, Ghana and Togo is recognized as a key actor for health and border activities by governments and supports Member States to improve policies, legislation, operational systems, and human resources to address migration and border management challenges.

Key Operating Modalities
Participation and empowerment Conflict sensitivity Integrated Programming Collaboration and partnership Localization
Cross-cutting priorities
Data and evidence Protection Mainstreaming Gender Equality Prevention of sexual exploitation and abuse Disaster Risk Climate Change Law and policy

The HBMM framework promotes a multisectoral approach to health crises. This approach emphasizes preparedness, response and resilient recovery while considering population mobility, cross-border dynamics, and vulnerable communities along the mobility contiuum. It aligns with IOM's Localization Framework, which links humanitarian interventions to sustainable development for long-term health system resilience at all levels. 

IOM’s response prioritizes direct implementation and service delivery at the local and national levels.  This approach involves building partnerships with local and national actors (LNAs), including governments, community leaders, and CSOs. Simultaneously, IOM encourages LNAs and communities to be active participants and engaged in the implementation of activities, to ensure that interventions leverage local expertise and capacities in the dynamic context. Capacity strengthening and participation of LNAs and affected populations are integral to this Mpox preparedness and response plan.

Objective 1 - Saving lives and protecting people on the move
Saving lives and protecting people on the move

$27,914,400
Funding required
2,911,161
People Targeted
58
Entities Targeted
Primary target groups
Internally displaced person
Local population / community
Internal migrant
Refugee
International migrant

IOM will aim to achieve: (1) evidence-based public health responses to mpox and other communicable diseases through an understanding of population mobility to inform the delivery of assistance to crisis-affected populations; and (2) mobility-sensitive and inclusive health, including border health, systems and services to crisis-affected populations for the prevention and early detection of disease.  This objective also comprises a range of activities to enhance the technical and operational capacity of health systems to deliver mobility-sensitive health services, along with border health capacity. Planned activities, including the integration of MHPSS principles, will contribute to reduce the threats and vulnerabilities experienced by crisis-affected populations by enhancing the evidence base on the human mobility dimensions of communicable disease. Additionally, the activities will build health system and border health capacity at PoEs and along the mobility continuum to uphold the dignity and rights of people affected by crisis and reduce barriers to access quality health care services that respond to their needs. 

Objective 2 - Driving solutions to displacement
Driving solutions to displacement

$11,651,298
Funding required
2,145,975
People Targeted
55
Entities Targeted
Primary target groups
Internally displaced person
Local population / community
Internal migrant
Refugee
International migrant

IOM will aim to (1) improve population awareness, trust, behavioural change, and community engagement in response to mpox and other communicable disease threats through access to relevant and critical information about health risks; (2) address health emergencies in coordination with governments and communities in a way that is responsive to the needs of migrants and mobile populations ; and (3) strengthen health systems to create a safe, secure living environment for affected communities and to respond to their needs, with special attention to vulnerable and marginalized groups.    RCCE activities will include women, youth, and marginalized populations by reaching out to through community health workers (CHWs) and other community-based actors and addressing potential stigmatization faced by vulnerable groups. Planned activities will enhance community engagement based on IOM’s community-based planning methodology and empower people affected by crisis through communicable disease prevention and response at PoEs and along the mobility pathway to be resilient to health emergencies, as well as at sites for displaced people in cooperation with CCCM teams. This objective will also support the long-term development of mobility sensitive health systems that are inclusive of migrants, mobile populations, and cross-border communities for communicable disease prevention, detection and response.

Facilitating pathways for regular migration
Facilitating pathways for regular migration

$6,526,080
Funding required
2,119,140
People Targeted
54
Entities Targeted
Primary target groups
Internally displaced person
Local population / community
Internal migrant
Refugee
International migrant

IOM will aim to achieve: (1) policy, legal, and strategic frameworks that are coordinated through a whole-of-governmental approach, align with international standards, and protect and promote public health and the rights of migrants including IDPs, migrant workers, mobile populations, and communities near borders and in migrant-dense areas; and (2) enhanced multisectoral and cross-border collaboration for mpox and other communicable disease preparedness, prevention, detection and response. The enhanced collaboration will  improve the management of migration flows and cross-border mobility to ensure the health, security, and safety of migrants and other mobile populations, along the mobility continuum.  Interventions focus on advocacy and technical support to ensure that governments mainstream migration in related policies and strategic decision-making across sectors and agendas, promote mobility-sensitive health systems and responses to ensure migrants including IDPs have access to essential healthcare along migration routes and the risks that population mobility may pose to individuals and public health are mitigated. By fostering an enabling environment for migrant-inclusive public health action, IOM will aim to increase the effectiveness of measures to prevent, detect, and respond to health threats at the local, national, regional, and continental levels while contributing to realizing universal health coverage through facilitating access to health services for migrants and mobile populations. This objective also facilitates multisectoral dialogue and coordination across borders through developing cross-border information sharing platform and using mobility and surveillance data for preparedness and response to health emergencies.  Through these efforts, this objective will enable safe population mobility without unwarranted travel restrictions and limit the transmission of health threats across borders.

Objective 1
Saving lives and protecting people on the move
$27,914,400
Funding required
[{"name":"Human suffering is alleviated","y":63},{"name":"Threats and vulnerabilities are reduced","y":27},{"name":"The quality of humanitarian assistance is enhanced","y":10}]
Objective 2
Driving solutions to displacement
$11,651,298
Funding required
[{"name":"Adverse drivers of displacement are minimized","y":20},{"name":"Displaced people are resilient and self-reliant","y":80}]
Objective 3
Facilitating pathways for regular migration
$6,526,080
Funding required
[{"name":"Migration flows and cross-border mobility are well managed","y":34},{"name":"Migration policy and legal frameworks are aligned with international standards","y":44},{"name":"Migrants are protected from violence, exploitation and abuse","y":22}]

Percentage of funding required contributing to the long term outcomes expressed on IOM's Strategic Results Framework.

$1,342,478
Funding required
Related inter agency plans
FA

The health implications of protection violations need to be addressed throughout all stages of the health response to crises because public health emergencies can exacerbate pre-existing vulnerabilities and risks of violence and discrimination, which can intersect with other factors such as gender, age, disability, nationality, status and/or ethnic origin. IOM is committed to ensuring that protection, gender equality, age, and disability considerations are taken into account at every step of its health programming, while targeting at-risk groups, to ensure that its approach is gender/vulnerability-responsive and inclusive. Protection principles will be mainstreamed across interventions to ensure safety and dignity, avoid causing harm and guarantee meaningful access to assistance for all the persons in need, without discrimination. 

IOM supports the continuum of critical protection mechanisms and responses during public health and other emergencies, including across borders, in order to provide urgent protection services and referrals to appropriate services to those most in need.

$1,342,478
Funding required
[["Saving lives",61],["Solutions to displacement",25],["Pathways for regular migration",14]]
IOM conducts a training for community health workers on Mpox awareness raising in Zimbabwe. © IOM 2024
IOM conducts a training for community health workers on Mpox awareness raising in Zimbabwe. © IOM 2024
Health
$42,541,300 Funding required
Related inter agency plans FA H(N)RP UNSDCF
Mental health and psychosocial support
$2,208,000 Funding required
Related inter agency plans FA H(N)RP UNSDCF
Operational presence in

Algeria, Angola, Benin, Burundi, Cameroon, Côte d'Ivoire, Democratic Republic of the Congo, Egypt, Eswatini, Gambia, Ghana, Guinea, Kenya, Lesotho, Libya, Malawi, Morocco, Mozambique, Nigeria, Rwanda, Sierra Leone, South Africa, South Sudan, Sudan, United Republic of Tanzania, Togo, Tunisia, Uganda, Zambia, Zimbabwe

 

The map used here is for illustration purposes only. Names and boundaries do not imply official endorsement or acceptance by IOM.

Figures are as of 31 December 2023. For more details of IOM's operational capacity in country, please see the IOM Capacity section.